Selected Publications

Complete Publication List at Pubmed

  1. Urban S.L., I.J. Jensen, Q. Shan, L.L. Pewe, H.H. Xue, V.P. Badovinac, J.T. Harty (2020) Peripherally induced brain tissue-resident memory CD8+ T cells mediate protection against CNS infection. Nat Immunol. Aug;21(8):938-949. doi: 10.1038/s41590-020-0711-8. Epub 2020 Jun 22. PMCID: PMC7381383 [available on 2020-12-22]
  2. Kurup S.P., N.S. Butler, J.T. Harty (2019) T cell-mediated immunity to malaria. Nat Rev Immunol. Jul;19(7):457-471. Review PMCID: PMC6599480
  3. Kurup S.P., S.M. Anthony, L.S. Hancox, R. Vijay, L.L. Pewe, S.J. Moioffer, R. Sompallae, C.J. Janse, S.M. Khan, J.T. Harty (2019) Monocyte-Derived CD11c+ Cells Acquire Plasmodium from Hepatocytes to Prime CD8 T Cell Immunity to Liver-Stage Malaria. Cell Host Microbe. Mar 13. pii: S1931-3128(19)30110-6. PMCID: PMC6459714
  4. Van Braeckel-Budimir, N., S.M. Varga, V.P. Badovinac, and J.T. Harty (2018) Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8+ T Cells and Heterosubtypic Immunity. Cell Reports, 24(13): 3374-3382.e3 PMCID: PMC6258017
  5. Kurup, S. P., N. Obeng-Adjei, S. M. Anthony, B. Traore, O. K. Doumbo, N. S. Butler, P. D. Crompton and J.T. Harty (2017) Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4. Nature Medicine, 23(10):1220-1225. PMCID: PMC5649372
  6. Van Braeckel-Budimir, N., S. Gras, K. Ladell, T.M. Josephs, L. Pewe, S.L. Urban, K.L. Miners, C. Farenc, D.A. Price, J. Rossjohn, J.T. Harty (2017) A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene. Immunity, 2017 PMCID: PMC5724374
  7. *Slutter, B, *N. van Breackel-Budimir, G. Abboud, S. Salek-Ardakani, S. M. Varga and J.T. Harty (2017) Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity. Science Immunology, 06 Jan 2017: Vol. 2, Issue 7. PMCID: PMC5590757
  8. Richer, M. J., L. L. Pewe, L.S. Hancox, S. M. Hartwig, S. M. Varga and J. T. Harty (2015) Inflammatory IL-15 is required for optimal memory CD8 T cell responses. Journal of Clinical Investigation. Aug 4. pii: 81261. PMCID: PMC4588296
  9. Nolz, J.C. and J.T. Harty (2014) IL-15 regulates memory CD8+ T cell O-glycan synthesis and affects trafficking.  Journal of Clinical Investigation, Mar 3;124(3):1013-26. PMCID PMC3934158 
  10. Starbeck-Miller, G., H.-H. Xue and J. T. Harty (2014) Inflammatory Cytokines Extend the Division of Activated CD8 T cells in vivo by Maintaining High Affinity IL-2 Signaling. Journal of Experimental Medicine, Jan 13;211(1):105-20. PMCID: PMC3892973
  11. Slutter, B., L. L. Pewe, S. M. Kaech and J. T. Harty (2013). Lung airway-surveilling CXCR3+ memory CD8 T cells are critical for protection against Influenza A virus. Immunity, 39: 939-948. PMCID: PMC3872058
  12. Richer, M. J., J. C. Nolz and J. T. Harty (2013) Pathogen-specific inflammatory milieux tune the antigen sensitivity of CD8 T cells by enhancing TCR signaling.  Immunity.  2013 Jan 24;38(1):140-52. PMCID: PMC3557574
  13. Nolz, J. C., D. Rai, V.P. Badovinac and J. T. Harty (2012) Division-linked generation of death-intermediates regulates the numerical stability of memory CD8 T cells. Proceedings of the National Academy of Sciences. 109(16):6199-204. PMCID: PMC3341021.
  14. Butler, N.S., J. Moebius, L. Pewe, B. Traore, O. K. Doumbo, L. Tygrett, T. Waldschmidt, *P. D. Crompton and *J.T. Harty (2011) Therapeutic PD-L1 and LAG-3 blockade rapidly clears established blood-stage Plasmodium infection. Nature Immunology. 13:188-195. PMCID: PMC3262959.
  15. Nolz, J.C. and J. T. Harty (2011) Protective Capacity of Memory CD8 T Cells is Dictated by Antigen Exposure History and Nature of the Infection. Immunity. 34: 781-793. PMCID: PMC3103642.
  16. *N. S. Butler, *N. W. Schmidt, A. M. Vaughan, A. S. Aly, #S. H. I. Kappe, #J. T. Harty (2011) Superior anti-malarial immunity after vaccination with late-liver-stage arresting genetically attenuated parasites. Cell Host and Microbe. 9: 451-462. PMCID: PMC3117254. *co-first authors #co-corresponding authors
  17. Wirth, T.C., D. Rai, J.T. Sabel, T. Bair, H.-H. Xue, J.T. Harty* and V.P. Badovinac* (2010) Stepwise transcriptosome diversification in repetitively stimulated memory CD8 T cells. Immunity. 33:128-40. PMCID: PMC2912220.
  18. Schmidt, N.W., *N.S. Butler, V.P. Badovinac and J.T. Harty (2010) Extreme CD8 T-cell requirements for anti-malarial liver-stage immunity following whole-parasite vaccination. PLOS Pathogens.  6: e1000998. doi:10.1371/journal.ppat.1000998 PMCID: PMC2904779. *co-first authors 
  19. Pham, N.-L.L., L. L. Pewe, C. J. Fleenor, R. A. Langlois, K. L. Legge, V.P. Badovinac, and J. T. Harty (2010) Exploiting cross-priming to rapidly generate protective CD8 T cell immunity. Proceedings of the National Academy of Sciences, 107: 12198-12203. PMCID: PMC2901444
  20. Schmidt, N.W., R. L. Podyminogin, N. S. Butler, V.P. Badovinac B.J. Tucker, A. Reyes-Sandoval, C. L. Hutchings, A. C. Moore, S. C. Gilbert, A. V. Hill, L. C. Bartholomay, and J. T. Harty (2008) Memory CD8 T cell responses exceeding a large, but definable threshold provide long-term immunity to malaria. Proceedings of the National Academy of Sciences: 105:14017-14022. PMCID: PMC2544571.
  21. Badovinac, V.P., J.S. Haring and J. T. Harty (2007) Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8 T cell response to infection. Immunity. 26: 827-841. PMCID: PMC1989155
  22. Jabbari, A. and J.T. Harty. (2006) Secondary memory CD8 T cells are more protective but slower to acquire a central memory phenotype. Journal of Experimental Medicine. 203:919-932. PMCID: PMC2118270
  23. *Badovinac, V.P., *K.A.N. Messingham, A. Jabbari, J.S. Haring and J. T. Harty (2005) Accelerated generation of memory CD8+ T cells and prime-boost response after dendritic cell vaccination. Nature Medicine. 11: 748-756.Pubmed Abstract.
  24. Badovinac, V. P., B. Porter and J.T. Harty. (2004) Early inflammation controls CD8+ T cell contraction. Nature Immunology. 5: 809-817. Pubmed Abstract.
  25. Hamilton. S.E., B.P. Porter, K.A.N. Messingham, V. P. Badovinac and J. T. Harty (2004) MHC class Ia-restricted memory T-cells inhibit expansion of a non-protective class Ib-(H2-M3) restricted memory response. Nature Immunology. 5:159-168. Pubmed Abstract.
  26. Badovinac, V. P. S.E. Hamilton and J.T. Harty. (2003) Viral infection results in massive CD8+ T cell expansion and mortality in vaccinated perforin-deficient mice. Immunity. 18: 463-474. Pubmed Abstract.
  27. Badovinac, V. P., B. Porter and J.T. Harty. (2002). Programmed contraction of CD8+ T cells after infection. Nature Immunology. 3: 619-626. Pubmed Abstract.
  28. Badovinac, V. P., A. Tvinnereim and J. T. Harty. (2000). Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma. Science. 290: 1354-1357 Pubmed Abstract.
  29. Shen, H., J. F. Miller, X. Fan, D. Kolwyck, R. Ahmed and J. T. Harty (1998) Bacterial antigen compartmentalization: differential effects on priming of CD8 T cells and protective immunity. 
    Cell. 92: 535-545. Pubmed Abstract.