Selected Publications

Complete Publication List at Pubmed

  1. Lefebvre M.N., Surette F.A., Anthony S.M., Vijay R., Jensen I.J., Pewe L.L., Hancox L.S., Van Braeckel-Budimir N,. van de Wall S., Urban S.L., Mix M.R., Kurup S.P., Badovinac V.P., Butler N.S., and J.T. Harty (2021) Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria. Cell Rep. 2;37(5):109956. PMID: 34731605; PMCID: PMC8628427.
  2. Anthony S.M., Van Braeckel-Budimir N., Moioffer S.J., van de Wall S., Shan Q., Vijay R., Sompallae R., Hartwig S.M., Jensen I.J., Varga S.M., Butler N.S., Xue H.H., Badovinac V.P., and J.T. Harty (2021) Protective function and durability of mouse lymph node-resident memory CD8+ T cells. Elife. 10:e68662. PMID: 34143731; PMCID: PMC8213409.
  3. Urban SL, Jensen IJ, Shan Q, Pewe LL, Xue HH, Badovinac VP, Harty JT. Peripherally induced brain tissue-resident memory CD8+ T cells mediate protection against CNS infection. Nat Immunol. 2020 Aug;21(8):938-949. Epub 2020 Jun 22. PMID: 32572242; PMCID: PMC7381383 
  4. Kurup S.P., N.S. Butler, J.T. Harty (2019) T cell-mediated immunity to malaria. Nat Rev Immunol. Jul;19(7):457-471. Review PMCID: PMC6599480
  5. Kurup S.P., S.M. Anthony, L.S. Hancox, R. Vijay, L.L. Pewe, S.J. Moioffer, R. Sompallae, C.J. Janse, S.M. Khan, J.T. Harty (2019) Monocyte-Derived CD11c+ Cells Acquire Plasmodium from Hepatocytes to Prime CD8 T Cell Immunity to Liver-Stage Malaria. Cell Host Microbe. Mar 13. pii: S1931-3128(19)30110-6. PMCID: PMC6459714
  6. Van Braeckel-Budimir, N., S.M. Varga, V.P. Badovinac, and J.T. Harty (2018) Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8+ T Cells and Heterosubtypic Immunity. Cell Reports, 24(13): 3374-3382.e3 PMCID: PMC6258017
  7. Kurup, S. P., N. Obeng-Adjei, S. M. Anthony, B. Traore, O. K. Doumbo, N. S. Butler, P. D. Crompton and J.T. Harty (2017) Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4. Nature Medicine, 23(10):1220-1225. PMCID: PMC5649372
  8. Van Braeckel-Budimir, N., S. Gras, K. Ladell, T.M. Josephs, L. Pewe, S.L. Urban, K.L. Miners, C. Farenc, D.A. Price, J. Rossjohn, J.T. Harty (2017) A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene. Immunity, 2017 PMCID: PMC5724374
  9. *Slutter, B, *N. van Breackel-Budimir, G. Abboud, S. Salek-Ardakani, S. M. Varga and J.T. Harty (2017) Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity. Science Immunology, 06 Jan 2017: Vol. 2, Issue 7. PMCID: PMC5590757
  10. Richer, M. J., L. L. Pewe, L.S. Hancox, S. M. Hartwig, S. M. Varga and J. T. Harty (2015) Inflammatory IL-15 is required for optimal memory CD8 T cell responses. Journal of Clinical Investigation. Aug 4. pii: 81261. PMCID: PMC4588296
  11. Nolz, J.C. and J.T. Harty (2014) IL-15 regulates memory CD8+ T cell O-glycan synthesis and affects trafficking.  Journal of Clinical Investigation, Mar 3;124(3):1013-26. PMCID PMC3934158 
  12. Starbeck-Miller, G., H.-H. Xue and J. T. Harty (2014) Inflammatory Cytokines Extend the Division of Activated CD8 T cells in vivo by Maintaining High Affinity IL-2 Signaling. Journal of Experimental Medicine, Jan 13;211(1):105-20. PMCID: PMC3892973
  13. Slutter, B., L. L. Pewe, S. M. Kaech and J. T. Harty (2013). Lung airway-surveilling CXCR3+ memory CD8 T cells are critical for protection against Influenza A virus. Immunity, 39: 939-948. PMCID: PMC3872058
  14. Richer, M. J., J. C. Nolz and J. T. Harty (2013) Pathogen-specific inflammatory milieux tune the antigen sensitivity of CD8 T cells by enhancing TCR signaling.  Immunity.  2013 Jan 24;38(1):140-52. PMCID: PMC3557574
  15. Nolz, J. C., D. Rai, V.P. Badovinac and J. T. Harty (2012) Division-linked generation of death-intermediates regulates the numerical stability of memory CD8 T cells. Proceedings of the National Academy of Sciences. 109(16):6199-204. PMCID: PMC3341021.
  16. Butler, N.S., J. Moebius, L. Pewe, B. Traore, O. K. Doumbo, L. Tygrett, T. Waldschmidt, *P. D. Crompton and *J.T. Harty (2011) Therapeutic PD-L1 and LAG-3 blockade rapidly clears established blood-stage Plasmodium infection. Nature Immunology. 13:188-195. PMCID: PMC3262959.
  17. Nolz, J.C. and J. T. Harty (2011) Protective Capacity of Memory CD8 T Cells is Dictated by Antigen Exposure History and Nature of the Infection. Immunity. 34: 781-793. PMCID: PMC3103642.
  18. *N. S. Butler, *N. W. Schmidt, A. M. Vaughan, A. S. Aly, #S. H. I. Kappe, #J. T. Harty (2011) Superior anti-malarial immunity after vaccination with late-liver-stage arresting genetically attenuated parasites. Cell Host and Microbe. 9: 451-462. PMCID: PMC3117254. *co-first authors #co-corresponding authors
  19. Wirth, T.C., D. Rai, J.T. Sabel, T. Bair, H.-H. Xue, J.T. Harty* and V.P. Badovinac* (2010) Stepwise transcriptosome diversification in repetitively stimulated memory CD8 T cells. Immunity. 33:128-40. PMCID: PMC2912220.
  20. Schmidt, N.W., *N.S. Butler, V.P. Badovinac and J.T. Harty (2010) Extreme CD8 T-cell requirements for anti-malarial liver-stage immunity following whole-parasite vaccination. PLOS Pathogens.  6: e1000998. doi:10.1371/journal.ppat.1000998 PMCID: PMC2904779. *co-first authors 
  21. Pham, N.-L.L., L. L. Pewe, C. J. Fleenor, R. A. Langlois, K. L. Legge, V.P. Badovinac, and J. T. Harty (2010) Exploiting cross-priming to rapidly generate protective CD8 T cell immunity. Proceedings of the National Academy of Sciences, 107: 12198-12203. PMCID: PMC2901444
  22. Schmidt, N.W., R. L. Podyminogin, N. S. Butler, V.P. Badovinac B.J. Tucker, A. Reyes-Sandoval, C. L. Hutchings, A. C. Moore, S. C. Gilbert, A. V. Hill, L. C. Bartholomay, and J. T. Harty (2008) Memory CD8 T cell responses exceeding a large, but definable threshold provide long-term immunity to malaria. Proceedings of the National Academy of Sciences: 105:14017-14022. PMCID: PMC2544571.
  23. Badovinac, V.P., J.S. Haring and J. T. Harty (2007) Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8 T cell response to infection. Immunity. 26: 827-841. PMCID: PMC1989155
  24. Jabbari, A. and J.T. Harty. (2006) Secondary memory CD8 T cells are more protective but slower to acquire a central memory phenotype. Journal of Experimental Medicine. 203:919-932. PMCID: PMC2118270
  25. *Badovinac, V.P., *K.A.N. Messingham, A. Jabbari, J.S. Haring and J. T. Harty (2005) Accelerated generation of memory CD8+ T cells and prime-boost response after dendritic cell vaccination. Nature Medicine. 11: 748-756.Pubmed Abstract.
  26. Badovinac, V. P., B. Porter and J.T. Harty. (2004) Early inflammation controls CD8+ T cell contraction. Nature Immunology. 5: 809-817. Pubmed Abstract.
  27. Hamilton. S.E., B.P. Porter, K.A.N. Messingham, V. P. Badovinac and J. T. Harty (2004) MHC class Ia-restricted memory T-cells inhibit expansion of a non-protective class Ib-(H2-M3) restricted memory response. Nature Immunology. 5:159-168. Pubmed Abstract.
  28. Badovinac, V. P. S.E. Hamilton and J.T. Harty. (2003) Viral infection results in massive CD8+ T cell expansion and mortality in vaccinated perforin-deficient mice. Immunity. 18: 463-474. Pubmed Abstract.
  29. Badovinac, V. P., B. Porter and J.T. Harty. (2002). Programmed contraction of CD8+ T cells after infection. Nature Immunology. 3: 619-626. Pubmed Abstract.
  30. Badovinac, V. P., A. Tvinnereim and J. T. Harty. (2000). Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma. Science. 290: 1354-1357 Pubmed Abstract.
  31. Shen, H., J. F. Miller, X. Fan, D. Kolwyck, R. Ahmed and J. T. Harty (1998) Bacterial antigen compartmentalization: differential effects on priming of CD8 T cells and protective immunity. 
    Cell. 92: 535-545. Pubmed Abstract.