Training

2018: Ph.D., Department of Medical Microbiology, Tumor Virology and Cancer Immunotherapy, University of Groningen, Groningen, The Netherlands
2011: M.A., Infection and Immunity Program, Utrecht University, Utrecht, The Netherlands
2009: B.A., Biomedical Sciences, Specialization in Infectious Diseases, University of Edinburgh, Edinburgh, Scotland

Research

Lung resident memory CD8 T cell dynamics and protection from influenza virus.

Publications Pubmed

1. Silva EE, Moioffer SJ, Hassert M, Berton RR, Smith MG, van de Wall S, Meyerholz DK, Griffith TS, Harty JT, Badovinac VP. Defining Parameters That Modulate Susceptibility and Protection to Respiratory Murine Coronavirus MHV1 Infection. J Immunol. 2023 Dec 27:ji2300434. doi: 10.4049/jimmunol.2300434. Epub ahead of print. PMID: 38149923.
2. Drewry, LL, Pewe, LL, Hancox LS, van de Wall, S, Harty, JT; CD4 T Cell–Dependent and –Independent Roles for IFN-γ in Blood-Stage Malaria. J Immunol 2023; ji2200899. https://doi.org/10.4049/jimmunol.2200899
3. van de Wall, S, Crooks S, Varga, SM, Badovinac, VP, Harty, JT; Cutting Edge: Influenza-Induced CD11alo Airway CD103+ Tissue Resident Memory T Cells Exhibit Compromised IFN-γ Production after In Vivo TCR Stimulation. J Immunol 2023; ji2200931. https://doi.org/10.4049/jimmunol.2200931
4. Lefebvre MN, Surette FA, Anthony SM, Vijay R, Jensen IJ, Pewe LL, Hancox LS, Van Braeckel-Budimir N, van de Wall S, Urban SL, Mix MR, Kurup SP, Badovinac VP, Butler NS, Harty JT. Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria. Cell Rep. 2021 Nov 2;37(5):109956. PMID: 34731605; PMCID: PMC8628427.
5. Moioffer SJ,  Danahy DB, van de Wall S,  Jensen IJ, Sjaastad FV, Anthony SM, Harty JT,  Griffith TS, Badovinac VP.  Severity of Sepsis Determines the Degree of Impairment Observed in Circulatory and Tissue-Resident Memory CD8 T Cell Populations. J Immunol. 2021 Sep 3:ji2001142. DOI: 10.4049/jimmunol.2001142. Online ahead of print.
6. Anthony, SM, Van Braeckel-Budimir, N, Moioffer, SJ, van de Wall, S, Shan, Q, Vijay, R, Sompallae, R, Hartwig, SM, Jensen, IJ, Varga, SM, Butler, NS, Xue, HH, Badovinac, VP, Harty, JT.  Protective function and durability of mouse lymph node-resident memory CD8+ T cells. eLife 2021 Jun 18;10:e68662 DOI: 10.7554/eLife.68662
7. Komdeur, FL, Singh, A, van de Wall, S, …, Daemen, T.  First-in-Human Phase I Clinical Trial of an SFV-Based RNA Replicon Cancer Vaccine against HPV-Induced Cancers. Mol Ther 2021 Feb 3;29(2):611-625.  DOI: 10.1016/j.ymthe.2020.11.002. Epub 2020 Nov 5. PMID: 33160073; PMCID: PMC7854293
8. van de Wall, S, Badovinac, VP, Harty, JT.  Influenza-Specific Lung-Resident Memory CD8+ T Cells. Cold Spring Harb Perspect Biol 2021 Feb 1;13(2):a037978. DOI:10.1101/cshperspect.a037978 PMCID: PMC7849341
9. van de Wall, S, Santegoets, KCM, van Houtum, E, Bull, C, Adema, GJ.  Sialoglycans and Siglecs Can Shape the Tumor Immune Microenvironment. Trends Immunol. 2020 Apr;41(4):274-285. DOI: 10.1016/j.it.2020.02.001
10. Singh, A, Koutsoumpli, G, van de Wall, S, Daemen, T.  An alphavirus-based therapeutic cancer vaccine: from design to clinical trial. Cancer Immunol Immunother, 2019 May;68(5):849-859.  DOI: 10.1007/s00262-018-2276-z
11. van de Wall, S, Ljungberg, K, Ip, PP, Boerma, A, Knudsen, ML, Nijman, HW, Daemen, T.  Potent therapeutic efficacy of an alphavirus replicon DNA vaccine expressing human papilloma virus E6 and E7 antigens. Oncoimmunology, 2018 Jul 26;7(10):e1487913. doi:10.1080/2162402x.2018.1487913 PMCID: PMC6169581
12. Hartimath, SV, Draghiciu, O, van de Wall, S, Manuelli, V, Dierckx, RA, Nijman, HW, de Vries, EF.  Noninvasive monitoring of cancer therapy induced activated T cells using [(¹⁸)F]FB-IL-2 PET imaging. Oncoimmunology, 2016 Nov 18;6(1):e1248014. doi:10.1080/2162402x.2016.1248014 PMCID: PMC5283633
13. Komdeur, FL, Prins, TM, van de Wall, S, Plat, A, Wisman, GBA, Hollema, H, Nijman, HW.  CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer. Oncoimmunology, 2017 Jul 24;6(9):e1338230. doi:10.1080/2162402x.2017.1338230 PMCID: PMC559908
14. van de Wall, S, Walczak, M, van Rooij, N, Hoogeboom, BN, Meijerhof, T, Nijman, HW, Daemen, T.  Tattoo Delivery of a Semliki Forest Virus-Based Vaccine Encoding Human Papillomavirus E6 and E7. Vaccines (Basel), 2015 Mar 24;3(2):221-38. doi:10.3390/vaccines3020221 PMCID: PMC4494346
15. van de Wall, S, Nijman, HW, Daemen, T.  HPV-specific immunotherapy: key role for immunomodulators. Anticancer Agents Med Chem, 2014 Feb;14(2):265-79. DOI : 10.2174/187152061402140128163306