Lecia Epping
Lecia Epping

Research Assistant III 
lecia-pewe@uiowa.edu  

Department of Microbiology and Immunology
3-501 Bowen Science Building 
51 Newton Road 
University of Iowa 
Iowa City, IA 52242-1109

Lab: 319-335-9919
Fax: 319-335-9006 

Training

B.S. (Biology) Saint Ambrose University, Davenport, IA

Research

Design and develop experiments to determine the localization and distribution of CD8 T-cell memory cells during infections in splenic and liver tissues by confocal microscopy and multi-photon intravital imaging. 

Publications Pubmed

  1. Slütter B, Pewe LL, Kaech SM, Harty JT. Lung Airway-Surveilling CXCR3(hi) Memory CD8(+) T Cells Are Critical for Protection against Influenza A Virus. Immunity. 2013 Nov 14;39(5):939-48. PubMed PMID: 24238342. 
  2. Cabrera M, Pewe LL, Harty JT, Frevert U. In vivo CD8+ T Cell Dynamics in the Liver of Plasmodium yoelii Immunized and Infected Mice. PLoS One. 2013;8(8): e70842. doi: 10.1371/journal.pone.0070842.
  3. Butler NS, Moebius J, Pewe LL, Traore B, Doumbo OK, Tygrett LT, Waldschmidt TJ, Crompton PD, Harty JT. Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection. Nat Immunol. 2011 Dec 11;13(2):188-95. doi: 10.1038/ni.2180.
  4. Kashiwada M, Pham NL, Pewe LL, Harty JT, Rothman PB. NFIL3/E4BP4 is a key transcription factor for CD8α+ dendritic cell development. Blood. 2011 Jun 9;117(23):6193-7. Epub 2011 Apr 7.
  5. Khanolkar A, Fulton RB, Epping LL, Pham NL, Tifrea D, Varga SM, Harty JT. T cell epitope specificity and pathogenesis of mouse hepatitis virus-1-induced disease in susceptible and resistant hosts. J Immunol. 2010 Jul 15;185(2):1132-41.
  6. Pham NL, Pewe LL, Fleenor CJ, Langlois RA, Legge KL, Badovinac VP, Harty JT. Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12198-203.
  7. Khanolkar A, Hartwig SM, Haag BA, Meyerholz DK, Epping LL, Haring JS, Varga SM, Harty JT. Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome. J Virol. 2009 Sep;83(18):9258-72.

Publication acknowledgements of technical assistance:

  1. Schmidt NW, Harty JT. Cutting Edge: Attrition of Plasmodium-Specific Memory CD8 T Cells Results in Decreased Protection That Is Rescued by Booster Immunization. J Immunol. 2011 Feb 28. [Epub ahead of print]
  2. Butler NS, Schmidt NW, Harty JT. Differential effector pathways regulate memory CD8 T cell immunity against Plasmodium berghei versus P. yoelii sporozoites. J Immunol. 2010 Mar 1;184(5):2528-38. Epub 2010 Jan 22.
  3. Zhao DM, Yu S, Zhou X, Haring JS, Held W, Badovinac VP, Harty JT, Xue HH. Constitutive activation of Wnt signaling favors generation of memory CD8 T cells. J Immunol. 2010 Feb 1;184(3):1191-9. Epub 2009 Dec 21.
  4. Schmidt NW, Butler NS, Harty JT. CD8 T cell immunity to Plasmodium permits generation of protective antibodies after repeated sporozoite challenge. Vaccine. 2009 Oct 19;27(44):6103-6. Epub 2009 Aug 25.