​Samarchith Kurup, DVM, PhD

Postdoctoral Research Fellow 

Department of Microbiology and Immunology
3-501 Bowen Science Building
51 Newton Road
University of Iowa
Iowa City, IA 52242-1109

Lab: 319-335-9919
Fax: 319-335-9006


2013 Ph.D., Department of Cellular Biology, University of Georgia, Athens, GA, USA
2008 MVSc., Indian Veterinary Research Institute, UP, India
2006 DVM Kerala Agricultural University, Kerala, India


Interface of innate and adaptive immunity, with a focus on host-pathogen interactions. 


  • Immunoparasitology scholarship, Marine biological Laboratories (2014)
  • American Association of Immunologists (AAI) young investigator award (2013)
  • Marine Biological Laboratories-FAPESP-USP grant (2012)
  • The University of Georgia Graduate School 3MT Thesis award (2012)

Selected Publications Pubmed

  1. Kurup SP, Butler NS, Harty JT., T cell-mediated immunity to malaria. Nat Rev Immunol. 2019 Apr 2. doi: 10.1038/s41577-019-0158-z. [Epub ahead of print] Review.
  2. Kurup SP, Anthony SM, Hancox LS, Vijay R, Pewe LL, Moioffer SJ, Sompallae R, Janse CJ, Khan SM, Harty JT., Monocyte-Derived CD11c+ Cells Acquire Plasmodium from Hepatocytes to Prime CD8 T Cell Immunity to Liver-Stage Malaria. Cell Host Microbe. Mar 13. pii: S1931-3128(19)30110-6. doi: 10.1016/j.chom.2019.02.014.
  3. Kurup SP, Obeng-Adjei N, Anthony SM, Traore B, Doumbo OK, Butler NS, Crompton PD, Harty JT., Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4, Nat Medicine; 23(10):1220-1225 (2017) (Cover story) PMCID: PMC556421
  4. Shan Q, Zeng Z, Xing S, Li F, Hartwig SM, Gullicksrud JA, Kurup SP, Van Braeckel-Budimir N, Su Y, Martin MD, Varga SM, Taniuchi I, Harty JT, Peng W, Badovinac VP, Xue HH., The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage. Nat Immunology; 18(8):931-939 (2017) PMCID: PMC5564218.
  5. Vijay R, Fehr AR, Janowski AM, Athmer J, Wheeler DL, Grunewald M, Sompallae R, Kurup SP, Meyerholz DK, Sutterwala FS, Narumiya S, Perlman S., Virus-induced inflammasome activation is suppressed by prostaglandin D2/DP1 signaling, PNAS; 114(27):E5444-E5453 (2017) PMCID: PMC5502630 [Available on 2018-01-03].
  6. Kim MT, Kurup SP, Starbeck-Miller GR, Harty JT. Manipulating Memory CD8 T Cell Numbers by Timed Enhancement of IL-2 Signals. J Immunol. 197(5):1754-61 (2016)PMCID: PMC4992593.
  7. Van Braeckel-Budimir N*, Kurup SP*, Harty JT. Regulatory issues in immunity to liver and blood-stage malaria. Curr Opin Immunol. 42:91-97. Review. (2016) DOI: 10.1016/j.coi.2016.06.008.
  8. Doll KL, Pewe LL, Kurup SP, Harty JT. Discriminating Protective from Nonprotective Plasmodium-Specific CD8+ T Cell Responses. J Immunol. 196(10):4253-62. (2016) PMCID: PMC4868661.
  9. Tewari AK*, Kurup SP*, Baidya S, Barta JR, Sharma B. Protective antibody and cytokine responses in mice following immunization with recombinant beta-tubulin and subsequent Trypanosoma evansi challenge. Parasit Vectors., 8:580 (2015) PMCID: PMC4644280.
  10. Kurup SP, Harty JT. gammadelta T cells and immunity to human malaria in endemic regions. Annals of Translational Medicine. 2015;3(Suppl 1):S22. PMCID: PMC4437949.
  11. Kurup SP, Tarleton RL, The Trypanosoma cruzi flagellum is discarded via asymmetric division following invasion and provides early targets for protective CD8+ T cells. Cell Host Microbe 16(4):439-49 (2014) PMCID: PMC4194031.
  12. Ulrich PN, Lander N, Kurup SP, Reiss L, Brewer J, Miranda K, Docampo R., The Acidocalcisome Vacuolar Transporter Chaperone 4 Catalyzes the Synthesis of Polyphosphate in Insect-stages of Trypanosoma brucei and T. cruzi. J Eukaryot Microbiol; 61, 155–165 (2014) PMCID: PMC3959231.
  13. Kurup SP, Tarleton RL, Perpetual expression of PAMPs necessary for optimal control and clearance of a persistent pathogen. Nat commun 4:2616 (2013) PMCID: PMC4161029.
  14. Kundu K, Tewari AK, Kurup SP, Baidya S, Rao JR, Joshi P., Sero-surveillance for surra in cattle using native surface glycoprotein antigen from Trypanosoma evansi. Vet Parasitol., 23;196(3-4):258-64 (2013) DOI: 10.1016/j.vetpar.2013.04.013.
  15. Kurup SP, Tewari AK., Induction of protective immune responses in mice by a DNA vaccine encoding Trypanosoma evansi beta tubulin gene. Vet Parasitol. 187 (1-2):9-16 (2012) DOI: 10.1016/j.vetpar.2012.01.009
  16. Tewari AK, Rao JR, Kurup SP, Hira Ram, Mishra AK., Infection trial with Trypanosoma evansi on Clarias gariepinus. Indian Veterinary Journal., 87 (3): 230-231 (2010)
  17. Radhakrishnan S, Kurup SP, Banerjee PS., Endoparasitism in captive wild-caught snakes indigenous to Kerala, India. Zoo Biol., 28(3):253-8 (2009) DOI: 10.1002/zoo.20231
  18. Kurup SP, Azhahianambi P, Ghosh S., Effect of surface area to weight ratio of egg masses on the hatchability of Boophilus microplus eggs. J Vector Borne Dis. 45(2):164-9 (2008) [pdf]

*Equally contributing authors