Mariah Hassert, Ph.D.
Mariah Hassert, Ph.D.

Postdoctoral Research Scholar

Department of Pathology
25 S. Grand Ave, 1020 ML
University of Iowa 
Iowa City, IA 52242

Lab: 319-335-9919


2021:  Ph.D., Molecular Microbiology and Immunology, Saint Louis University- School of Medicine, St. Louis, MO, USA
2014:  B.A., Biology, University of Missouri-St. Louis, St. Louis, MO, USA


NIH F32 Fellowship “Antiviral Lung Resident Memory T Cell Maintenance and Reinvigoration” NIAID


Heterotypic immunity, T cell mediated immunity to influenza virus

Publications Pubmed

  1. Hassert, M*, Arumugam, S*, Harty, JT. Memory CD8+ T cell-mediated protection against liver-stage malaria. Immunol Rev. 2023; 00: 1- 20. doi:10.1111/imr.13202
  2. Hassert, M. and Harty, J.T. (2022) Tissue resident memory T cells- A new benchmark for the induction of vaccine-induced mucosal immunity. Frontiers in Immunology. Oct 04;
  3. Geerling, E., Murphy, V., Mai, M.C., Stone, E.T., Casals, A.G., Hassert, M., O’Dea, A.T., Cao, F., Donlin, M.J., Elagawany. M., Elegendy, B., Pardali, V., Giannakopoulou, E., Zoidis, G., Schiavone, D.V., Berkowitz, A.J., Agyemang, N.B., Murelli, R.P., Tavis, J.E., Pinto, A.K., & Brien, J.D. (2022) Metal coordinating inhibitors of Rift Valley fever virus replication. Plos One. Sep 16;17(9):e0274266. PMID: 36112605 PMCIDPMC9481026
  4. Stone, E.T., Hassert, M., Geerling, E., Wagner, C., Brien, J.D., Ebel, G.D., Hirsch, A.J., German, C., Smith, J.L., & Pinto, A.K. (2022) Balanced T and B cell responses are required for immune protection against Powassan virus in virus-like particle vaccination. Cell Rep. Feb 15;38(7):110388. PMID: 35172138 PMCIDPMC8919300
  5. Pinto, A. K.*, Hassert, M.*, Han, X., Barker, D., Carnelley, T., Branche, E., Steffen, T. L., Stone, E. T., Geerling, E., Viramontes, K. M., Nykiforuk, C., Toth, D., Shresta, S., Kodihalli, S., & Brien, J. D. (2021). The ability of Zika virus intravenous immunoglobulin to protect from or enhance Zika virus disease. Frontiers in Immunology, 12.
  6. Geerling, E., Stone, E. T., Steffen, T. L., Hassert, M., Brien, J. D., & Pinto, A. K. (2021). Obesity Enhances Disease Severity in Female Mice Following West Nile Virus Infection. Frontiers in Immunology, 12.
  7. Grady, S. F., Pinto, A. K., Hassert, M., D’Angelo, J. A., Brien, J. D., & Arnatt, C. K. (2021). Selective estrogen receptor modulator, tamoxifen, inhibits Zika virus infection. Journal of Medical Virology, 93(11), 6155–6162.
  8. Hassert, M., Steffen, T.L., Scroggins, S., Coleman, A.K., Schacham, E., Brien, J.D., Pinto, A.K. (2021) Heterologous flavivirus exposure provides varying degrees of cross-protection from Zika virus in a mouse model of infection. Journal of Virology.
  9. Wollner, C.J., Richner, M.C., Hassert, M., Pinto, A.K., Brien, J.D., Richner, J.M. (2021) A dengue virus serotype 1 mRNA-LNP vaccine elicits protective immune responses. Journal of Virology.
  10. Hassert, M., Geerling, E., Stone, E.T., Steffen, T.L., Feldman, M.S., Dickson, A.L., Class, J., Richner, J.M., Brien, J.D., Pinto, A.K. (2020) mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2. PLOS Pathogens. PMID: 33326500
  11. Hassert, M.*, Wolf, K.J.*, Rajeh, A., Shiebout, C., Hoft, S.G., Ahn, T.H., DiPaolo, R.J., Brien, J.D., Pinto, A.K., (2020) Diagnostic differentiation of Zika and dengue virus exposure by analyzing T cell receptor sequences from peripheral blood of infected HLA-A2 transgenic mice. PLOS Neglected Tropical Diseases. PMCID: PMC7738164
  12. Steffen, T.*, Hassert, M.*, Hoft, S.G., Stone, E.T., Zhang, J., Geerling, E., Grimberg, B.T., Roberts, M.S., Pinto, A.K., Brien, J.D. (2020) Immunogenicity and Efficacy of a Recombinant Human Adenovirus Type 5 vaccine against Zika Virus. Vaccines. PMCID: PMC7349816
  13. Serrano-Collazo, C., Pѐrez-Guzmàn, E.X., Pantoja, P., Hassert, M.,… Sariol, C.A. (2020). Effective control of early Zika virus replication by Dengue immunity is associated to the length of time between the 2 infections but not mediated by antibodies. PLOS Neglected Tropical Diseases. PMCID: PMC7255596
  14. Pѐrez-Guzmàn, E.X., Pantoja, P., Serrano-Collazo, C., Hassert, M., … Sariol, C.A. (2019). Time elapsed between Zika and dengue virus infections affects antibody and T cell responses. Nature Communications. PMCID: PMC6754404
  15. Brien, J.D.*, Hassert, M.*, Stone, E.T, Geerling, E., Cruz-Orengo, L., & Pinto, A.K. (2019). Isolation and quantification of Zika virus from multiple organs in a mouse. JoVE.
  16. Hassert, M., Harris, M.G., Brien, J.D., & Pinto, A.K. (2019). Identification of protective CD8+ T cell responses in mouse models of infection. Frontiers in Immunology, 10(1678). PMCID: PMC6652237
  17. Hassert, M., Brien, J.D., & Pinto, A.K. (2019). Mouse models of heterologous flavivirus immunity:  A role for cross-reactive T cells. Frontiers in Immunology, 10(1045). PMCID PMC6520664
  18. Hoyer, J. S., Pruneda-Paz, J. L., Breton, G., Hassert, M.., Holcomb, E. E., Fowler, H., . . . Carrington, J. C. (2018). Functional dissection of the ARGONAUTE7 promoter. Plant Direct.
  19. Hassert, M., Wolf, K. J., Schwetye, K. E., DiPaolo, R. J., Brien, J. D., & Pinto, A. K. (2018). CD4 T cells mediate protection against Zika associated severe disease in a mouse model of infection. PLOS Pathogens,14(9).
  20. Hassert, M., Brien, J. D., & Pinto, A. K. (2018). The Temporal Role of Cytokines in Flavivirus Protection and Pathogenesis. Current Clinical Microbiology Reports.
  21. Williams, J. N., Kambrath, A. V., Patel, R. B., Kang, K. S., Mével, E., Li, Y., Hassert, M., . . . Sankar, U. (2018). Inhibition of CaMKK2 Enhances Fracture Healing by Stimulating Indian Hedgehog Signaling and Accelerating Endochondral Ossification. Journal of Bone and Mineral Research,33(5), 930-944.
  22. Pantoja, P., Pérez-Guzmán, E. X., Rodríguez, I. V., White, L. J., González, O., Serrano, C., Hassert, M., . . . Sariol, C. A. (2017). Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus. Nature Communications,8, 15674.