Mariah Hassert, Ph.D.
Mariah Hassert, Ph.D.

Postdoctoral Research Scholar
mariah-hassert@uiowa.edu

Department of Pathology
25 S. Grand Ave, 1020 ML
University of Iowa 
Iowa City, IA 52242

Lab: 319-335-9919

Training

2021:  Ph.D., Molecular Microbiology and Immunology, Saint Louis University- School of Medicine, St. Louis, MO, USA
2014:  B.A., Biology, University of Missouri-St. Louis, St. Louis, MO, USA

Research

Heterotypic immunity, T cell mediated immunity to influenza virus

Publications Pubmed

  1. Pinto, A. K.*, Hassert, M.*, Han, X., Barker, D., Carnelley, T., Branche, E., Steffen, T. L., Stone, E. T., Geerling, E., Viramontes, K. M., Nykiforuk, C., Toth, D., Shresta, S., Kodihalli, S., & Brien, J. D. (2021). The ability of Zika virus intravenous immunoglobulin to protect from or enhance Zika virus disease. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.717425
  2. Geerling, E., Stone, E. T., Steffen, T. L., Hassert, M., Brien, J. D., & Pinto, A. K. (2021). Obesity Enhances Disease Severity in Female Mice Following West Nile Virus Infection. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.739025
  3. Grady, S. F., Pinto, A. K., Hassert, M., D’Angelo, J. A., Brien, J. D., & Arnatt, C. K. (2021). Selective estrogen receptor modulator, tamoxifen, inhibits Zika virus infection. Journal of Medical Virology, 93(11), 6155–6162. https://doi.org/10.1002/jmv.27230
  4. Hassert, M., Steffen, T.L., Scroggins, S., Coleman, A.K., Schacham, E., Brien, J.D., Pinto, A.K. (2021) Heterologous flavivirus exposure provides varying degrees of cross-protection from Zika virus in a mouse model of infection. Journal of Virology. https://doi.org/10.1128/JVI.00573-21.
  5. Wollner, C.J., Richner, M.C., Hassert, M., Pinto, A.K., Brien, J.D., Richner, J.M. (2021) A dengue virus serotype 1 mRNA-LNP vaccine elicits protective immune responses. Journal of Virology. https://doi.org/10.1128/JVI.02482-20
  6. Hassert, M., Geerling, E., Stone, E.T., Steffen, T.L., Feldman, M.S., Dickson, A.L., Class, J., Richner, J.M., Brien, J.D., Pinto, A.K. (2020) mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2. PLOS Pathogens. https://doi.org/10.1371/journal.ppat.1009163. PMID: 33326500
  7. Hassert, M.*, Wolf, K.J.*, Rajeh, A., Shiebout, C., Hoft, S.G., Ahn, T.H., DiPaolo, R.J., Brien, J.D., Pinto, A.K., (2020) Diagnostic differentiation of Zika and dengue virus exposure by analyzing T cell receptor sequences from peripheral blood of infected HLA-A2 transgenic mice. PLOS Neglected Tropical Diseases. https://doi.org/10.1371/journal.pntd.0008896. PMCID: PMC7738164
  8. Steffen, T.*, Hassert, M.*, Hoft, S.G., Stone, E.T., Zhang, J., Geerling, E., Grimberg, B.T., Roberts, M.S., Pinto, A.K., Brien, J.D. (2020) Immunogenicity and Efficacy of a Recombinant Human Adenovirus Type 5 vaccine against Zika Virus. Vaccines. https://doi.org/10.3390/vaccines8020170. PMCID: PMC7349816
  9. Serrano-Collazo, C., Pѐrez-Guzmàn, E.X., Pantoja, P., Hassert, M.,… Sariol, C.A. (2020). Effective control of early Zika virus replication by Dengue immunity is associated to the length of time between the 2 infections but not mediated by antibodies. PLOS Neglected Tropical Diseases. https://doi.org/10.1371/journal.pntd.0008285. PMCID: PMC7255596
  10. Pѐrez-Guzmàn, E.X., Pantoja, P., Serrano-Collazo, C., Hassert, M., … Sariol, C.A. (2019). Time elapsed between Zika and dengue virus infections affects antibody and T cell responses. Nature Communications. https://doi.org/10.1038/s41467-019-12295-2. PMCID: PMC6754404
  11. Brien, J.D.*, Hassert, M.*, Stone, E.T, Geerling, E., Cruz-Orengo, L., & Pinto, A.K. (2019). Isolation and quantification of Zika virus from multiple organs in a mouse. JoVE. https://doi.org/10.3791/59632
  12. Hassert, M., Harris, M.G., Brien, J.D., & Pinto, A.K. (2019). Identification of protective CD8+ T cell responses in mouse models of infection. Frontiers in Immunology, 10(1678). https://doi.org/10.3389/fimmu.2019.01678. PMCID: PMC6652237
  13. Hassert, M., Brien, J.D., & Pinto, A.K. (2019). Mouse models of heterologous flavivirus immunity:  A role for cross-reactive T cells. Frontiers in Immunology, 10(1045). https://doi.org/10.3389/fimmu.2019.01045. PMCID PMC6520664
  14. Hoyer, J. S., Pruneda-Paz, J. L., Breton, G., Hassert, M.., Holcomb, E. E., Fowler, H., . . . Carrington, J. C. (2018). Functional dissection of the ARGONAUTE7 promoter. Plant Direct. https://doi.org/10.1101/392910
  15. Hassert, M., Wolf, K. J., Schwetye, K. E., DiPaolo, R. J., Brien, J. D., & Pinto, A. K. (2018). CD4 T cells mediate protection against Zika associated severe disease in a mouse model of infection. PLOS Pathogens,14(9). https://doi.org/10.1371/journal.ppat.1007237
  16. Hassert, M., Brien, J. D., & Pinto, A. K. (2018). The Temporal Role of Cytokines in Flavivirus Protection and Pathogenesis. Current Clinical Microbiology Reports. https://doi.org/10.1007/s40588-018-0106-x
  17. Williams, J. N., Kambrath, A. V., Patel, R. B., Kang, K. S., Mével, E., Li, Y., Hassert, M., . . . Sankar, U. (2018). Inhibition of CaMKK2 Enhances Fracture Healing by Stimulating Indian Hedgehog Signaling and Accelerating Endochondral Ossification. Journal of Bone and Mineral Research,33(5), 930-944. https://doi.org/10.1002/jbmr.3379
  18. Pantoja, P., Pérez-Guzmán, E. X., Rodríguez, I. V., White, L. J., González, O., Serrano, C., Hassert, M., . . . Sariol, C. A. (2017). Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus. Nature Communications,8, 15674. https://doi.org/10.1038/ncomms15674