Mariah Hassert, Ph.D.
Mariah Hassert, Ph.D.

Postdoctoral Research Scholar
mariah-hassert@uiowa.edu

Department of Pathology
25 S. Grand Ave, 1020 ML
University of Iowa 
Iowa City, IA 52242
Lab: 319-335-9919

Training

2021:  Ph.D., Molecular Microbiology and Immunology, Saint Louis University- School of Medicine, St. Louis, MO, USA
2014:  B.A., Biology, University of Missouri-St. Louis, St. Louis, MO, USA

Awards

NIH F32 Fellowship “Antiviral Lung Resident Memory T Cell Maintenance and Reinvigoration” NIAID

Research

Heterotypic immunity, T cell mediated immunity to influenza virus

Publications Pubmed

  1. Hassert, M*, Arumugam, S*, Harty, JT. Memory CD8+ T cell-mediated protection against liver-stage malaria. Immunol Rev. 2023; 00: 1- 20. doi:10.1111/imr.13202
  2. Hassert, M. and Harty, J.T. (2022) Tissue resident memory T cells- A new benchmark for the induction of vaccine-induced mucosal immunity. Frontiers in Immunology. Oct 04; doi.org/10.3389/fimmu.2022.1039194.
  3. Geerling, E., Murphy, V., Mai, M.C., Stone, E.T., Casals, A.G., Hassert, M., O’Dea, A.T., Cao, F., Donlin, M.J., Elagawany. M., Elegendy, B., Pardali, V., Giannakopoulou, E., Zoidis, G., Schiavone, D.V., Berkowitz, A.J., Agyemang, N.B., Murelli, R.P., Tavis, J.E., Pinto, A.K., & Brien, J.D. (2022) Metal coordinating inhibitors of Rift Valley fever virus replication. Plos One. Sep 16;17(9):e0274266. PMID: 36112605 PMCID: PMC9481026
  4. Stone, E.T., Hassert, M., Geerling, E., Wagner, C., Brien, J.D., Ebel, G.D., Hirsch, A.J., German, C., Smith, J.L., & Pinto, A.K. (2022) Balanced T and B cell responses are required for immune protection against Powassan virus in virus-like particle vaccination. Cell Rep. Feb 15;38(7):110388. PMID: 35172138 PMCID: PMC8919300
  5. Pinto, A. K.*, Hassert, M.*, Han, X., Barker, D., Carnelley, T., Branche, E., Steffen, T. L., Stone, E. T., Geerling, E., Viramontes, K. M., Nykiforuk, C., Toth, D., Shresta, S., Kodihalli, S., & Brien, J. D. (2021). The ability of Zika virus intravenous immunoglobulin to protect from or enhance Zika virus disease. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.717425
  6. Geerling, E., Stone, E. T., Steffen, T. L., Hassert, M., Brien, J. D., & Pinto, A. K. (2021). Obesity Enhances Disease Severity in Female Mice Following West Nile Virus Infection. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.739025
  7. Grady, S. F., Pinto, A. K., Hassert, M., D’Angelo, J. A., Brien, J. D., & Arnatt, C. K. (2021). Selective estrogen receptor modulator, tamoxifen, inhibits Zika virus infection. Journal of Medical Virology, 93(11), 6155–6162. https://doi.org/10.1002/jmv.27230
  8. Hassert, M., Steffen, T.L., Scroggins, S., Coleman, A.K., Schacham, E., Brien, J.D., Pinto, A.K. (2021) Heterologous flavivirus exposure provides varying degrees of cross-protection from Zika virus in a mouse model of infection. Journal of Virology. https://doi.org/10.1128/JVI.00573-21.
  9. Wollner, C.J., Richner, M.C., Hassert, M., Pinto, A.K., Brien, J.D., Richner, J.M. (2021) A dengue virus serotype 1 mRNA-LNP vaccine elicits protective immune responses. Journal of Virology. https://doi.org/10.1128/JVI.02482-20
  10. Hassert, M., Geerling, E., Stone, E.T., Steffen, T.L., Feldman, M.S., Dickson, A.L., Class, J., Richner, J.M., Brien, J.D., Pinto, A.K. (2020) mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2. PLOS Pathogens. https://doi.org/10.1371/journal.ppat.1009163. PMID: 33326500
  11. Hassert, M.*, Wolf, K.J.*, Rajeh, A., Shiebout, C., Hoft, S.G., Ahn, T.H., DiPaolo, R.J., Brien, J.D., Pinto, A.K., (2020) Diagnostic differentiation of Zika and dengue virus exposure by analyzing T cell receptor sequences from peripheral blood of infected HLA-A2 transgenic mice. PLOS Neglected Tropical Diseases. https://doi.org/10.1371/journal.pntd.0008896. PMCID: PMC7738164
  12. Steffen, T.*, Hassert, M.*, Hoft, S.G., Stone, E.T., Zhang, J., Geerling, E., Grimberg, B.T., Roberts, M.S., Pinto, A.K., Brien, J.D. (2020) Immunogenicity and Efficacy of a Recombinant Human Adenovirus Type 5 vaccine against Zika Virus. Vaccines. https://doi.org/10.3390/vaccines8020170. PMCID: PMC7349816
  13. Serrano-Collazo, C., Pѐrez-Guzmàn, E.X., Pantoja, P., Hassert, M.,… Sariol, C.A. (2020). Effective control of early Zika virus replication by Dengue immunity is associated to the length of time between the 2 infections but not mediated by antibodies. PLOS Neglected Tropical Diseases. https://doi.org/10.1371/journal.pntd.0008285. PMCID: PMC7255596
  14. Pѐrez-Guzmàn, E.X., Pantoja, P., Serrano-Collazo, C., Hassert, M., … Sariol, C.A. (2019). Time elapsed between Zika and dengue virus infections affects antibody and T cell responses. Nature Communications. https://doi.org/10.1038/s41467-019-12295-2. PMCID: PMC6754404
  15. Brien, J.D.*, Hassert, M.*, Stone, E.T, Geerling, E., Cruz-Orengo, L., & Pinto, A.K. (2019). Isolation and quantification of Zika virus from multiple organs in a mouse. JoVE. https://doi.org/10.3791/59632
  16. Hassert, M., Harris, M.G., Brien, J.D., & Pinto, A.K. (2019). Identification of protective CD8+ T cell responses in mouse models of infection. Frontiers in Immunology, 10(1678). https://doi.org/10.3389/fimmu.2019.01678. PMCID: PMC6652237
  17. Hassert, M., Brien, J.D., & Pinto, A.K. (2019). Mouse models of heterologous flavivirus immunity:  A role for cross-reactive T cells. Frontiers in Immunology, 10(1045). https://doi.org/10.3389/fimmu.2019.01045. PMCID PMC6520664
  18. Hoyer, J. S., Pruneda-Paz, J. L., Breton, G., Hassert, M.., Holcomb, E. E., Fowler, H., . . . Carrington, J. C. (2018). Functional dissection of the ARGONAUTE7 promoter. Plant Direct. https://doi.org/10.1101/392910
  19. Hassert, M., Wolf, K. J., Schwetye, K. E., DiPaolo, R. J., Brien, J. D., & Pinto, A. K. (2018). CD4 T cells mediate protection against Zika associated severe disease in a mouse model of infection. PLOS Pathogens,14(9). https://doi.org/10.1371/journal.ppat.1007237
  20. Hassert, M., Brien, J. D., & Pinto, A. K. (2018). The Temporal Role of Cytokines in Flavivirus Protection and Pathogenesis. Current Clinical Microbiology Reports. https://doi.org/10.1007/s40588-018-0106-x
  21. Williams, J. N., Kambrath, A. V., Patel, R. B., Kang, K. S., Mével, E., Li, Y., Hassert, M., . . . Sankar, U. (2018). Inhibition of CaMKK2 Enhances Fracture Healing by Stimulating Indian Hedgehog Signaling and Accelerating Endochondral Ossification. Journal of Bone and Mineral Research,33(5), 930-944. https://doi.org/10.1002/jbmr.3379
  22. Pantoja, P., Pérez-Guzmán, E. X., Rodríguez, I. V., White, L. J., González, O., Serrano, C., Hassert, M., . . . Sariol, C. A. (2017). Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus. Nature Communications,8, 15674. https://doi.org/10.1038/ncomms15674