Lisa Hancox

Research Assistant III 

Department of Pathology
25 S. Grand Ave, 1020 ML
University of Iowa 
Iowa City, IA 52242

Lab: 319-335-9919


B.A. Cornell College, Mount Vernon, Iowa


Design and execute specialized research in the study of the immune system’s response to infection, as well as create new constructs for transgenic/knockout mouse models.

Publications Pubmed

  1. Lefebvre MN, Drewry LL, Pewe LL, Hancox LS, Reyes-Sandoval A, Harty JT. Cutting Edge: Subunit Booster Vaccination Confers Sterilizing Immunity against Liver-Stage Malaria in Mice Initially Primed with a Weight-Normalized Dose of Radiation-Attenuated Sporozoites. J Immunol. 2021 Dec 1;207(11):2631-2635. doi: 10.4049/jimmunol.2100818. Epub 2021 Oct 29. PMID: 34716185; PMCID: PMC8612975.
  2. Lefebvre MN, Surette FA, Anthony SM, Vijay R, Jensen IJ, Pewe LL, Hancox LS, Van Braeckel-Budimir N, van de Wall S, Urban SL, Mix MR, Kurup SP, Badovinac VP, Butler NS, Harty JT. Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria. Cell Rep. 2021 Nov 2;37(5):109956. doi: 10.1016/j.celrep.2021.109956. PMID: 34731605; PMCID: PMC8628427.
  3. Kurup SP, Anthony SM, Hancox LS, Vijay R, Pewe LL, Moioffer SJ, Sompallae R, Janse CJ, Khan SM, Harty JT. Monocyte-Derived CD11c+ Cells Acquire Plasmodium from Hepatocytes to Prime CD8 T Cell Immunity to Liver-Stage Malaria. Cell Host Microbe. 2019 Apr 10;25(4):565-577.e6. doi: 10.1016/j.chom.2019.02.014. Epub 2019 Mar 21. PMID: 30905437; PMCID: PMC6459714.
  4. Martin J. Richer, Lecia L. Pewe, Lisa S. Hancox, Stacey M. Hartwig, Steven M. Varga, John T. Harty. Inflammatory IL-15 is required for optimal memory T cell responses. J Clin Invest, 2015;125(9):3477-3490. DOI:10.1172/JCI81261.
  5. Simran Banga, Jill D. Coursen, Silvia Portugal, Tuan M. Tran, Lisa Hancox, Aissata Ongoiba, Boubacar Traore, Ogobara K. Doumbo, Chiung-Yu Huang, John T. Harty, Peter D. Crompton. Impact of acute malaria on pre-existing antibodies to viral and vaccine antigens in mice and humans. PLoS One. 2015; 10(4):e0125090. DOI: 10.1371/journal.pone.0125090.
  6. Aaron M Newman, Natasha B Gallo, Lisa S Hancox, Norma J Miller, Carolyn M Radeke, Michelle A Maloney, James B Cooper, Gregory S Hageman, Don H Anderson, Lincoln V Johnson and Monte J Radeke. Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks. Genome Medicine 2012, 4:16. DOI:10.1186/gm315
  7. Nathan W. Schmidt, Aaruni Khanolkar, Lisa Hancox, Jonathan W. Heusel, John T. Harty. Perforin plays an unexpected role in regulating T-cell contraction during prolonged Listeria monocytogenes infection. European Journal of Immunology. 12/2011. DOI: 10.1002/eji.201141902
  8. Don H. Anderson, Monte J. Radeke, Natasha B. Gallo, Ethan A. Chapin, Patrick T. Johnson, Christy R. Curletti, Lisa S. Hancox, Jane Hu, Jessica N. Ebright, Goldis Malek, Michael A. Hauser, Catherine Bowes-Rickman, Dean Bok, Gregory S. Hageman, and Lincoln V. Johnson. 2010. The Pivotal Role of the Complement System in Aging and Age-Related Macular Degeneration: Hypothesis Re-Visited. Progress in Retinal and Eye Research. 2010 Mar;29(2):95-112
  9. Allikmets, R., A. A. Bergen, M. Dean, R. H. Guymer, G. S. Hageman, C. C. Klaver, K. Stefansson, B. H. Weber, and the International AMD Genetics Consortium. 2009. Geographic atrophy in age-related macular degeneration and TLR3. N. Engl. J. Med. 360(21):2252-2254.
  10. Hageman GS, Hancox LS, Taiber AJ, Gehrs KM, Anderson DH, Johnson LV, Radeke MJ, Kavanagh D, Richards A, Atkinson J, Meri S, Bergeron J, Zernant J, Merriam J, Gold B, Allikmets R, Dean M, AMD Clinical Study Group. Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications. Annals of Medicine, 2006, 38(8):592-604.
  11. Gold B, Merriam JE, Zernant J, Hancox LS, Taiber AJ, Gehrs K, Cramer K, Neel J, Bergeron J, Barile GR, Smith RT, AMD Genetics Clinical Study Group, Hageman GS, Dean M, Allikmets R. Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genet. 2006 Apr;38(4):458-62.
  12. Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ, Hardisty LI, Hageman JL, Stockman HS, Borchardt JD, Gehrs KM, Smith RJ, Silvestri G, Russell SR, Klaver CC, Barbazetto I, Chang S, Yannuzzi LA, Barile GR, Merriam JC, Smith RT, Olsh AK, Bergeron J, Zernant J, Merriam JE, Gold B, Dean M, Allikmets R. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA. 2005 May 17;102(20):7227-32.
  13. Tinker, J.K., Hancox, L.S., and Clegg, S. FimW is a negative regulator affecting type I fimbrial expression in Salmonella enterica serovar typhimurium. J Bacteriol. 2001 Jan;183(2):435-442.
  14. Hancox, L.S., Clegg, S., and Yeh, K-S. Construction and characterization of type 1 non-fimbriate and non-adhesive mutants of Salmonella typhimurium. FEMS Immunol Med Microbiol. 1997 Dec;19(4):289-296.
  15. Clegg, S., Hancox, L.S., Yeh, K-S. 1996. Salmonella typhimurium fimbrial phase variation and fimA expression. J Bacteriol. 1996 Jan;178(2):542-545.
  16. Yeh, K-S., Hancox, L.S., and Clegg, S. 1995. Construction and characterization of a fimZ mutant of Salmonella typhimurim. J. of Bact. 1995 Dec;177(23):6861-6865.

Abstracts and Presentations

  1. Aaron M. Newman, Natasha Gallo, Lisa Hancox, Norma Miller, Carolyn Radeke, Don Anderson, Gregory Hageman, Lincoln Johnson, Monte Radeke. 2011. Novel Gene Expression Signatures Associated With AMD And Its Risk Factors. ARVO 2011 #2333 (11-A-5003-ARVO).
  2. E.N. Brown, L.S. Hancox, N.J. Miller, J.L. Hageman, C.M. Pappas, D.A. Hutcheson, M.A. Morrison, M.F. Leppert, M.M. DeAngelis, G.S. Hageman. 2010. Determination and Assessment of Extended Haplotypes Spanning the Chromosome 1q32 CFH-to-F13B Locus. ARVO 2010 (poster session).
  3. Lu, Q., L. Hancox, S. R. Russell, R. Stevenson, M. Campos, R. Pincheira, M. Hernandez, C. Araneda, P. Meza, A. Ormeno, R. Poblete and G. S. Hageman. 2004. Comparison of apolipoprotein E genotypes in Rapanui ad Caucasian populations support a role for this gene in the susceptibility toward age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. Suppl. 45: E-Abstract 1835.
  4. Bok, D., G. S. Hageman, J. Hu, L. Hancox, and Y. Wang. 2004. Expression and functional analyses of toll-like receptors in human retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. Suppl. 45: E-Abstract 636.
  5. Mullins, R. F., L. S. Hancox, and G. S. Hageman. 2000. The composition and biosynthesis of drusen: Immunohistochemical, molecular and proteomic analyses. Proc. Int. Soc. Eye Res. 14:S157.
  6. Hageman, G. S., L. Hancox and R. F. Mullins. 2000. Toward the characterization of pathways involved in the etiology of age-related macular degeneration: A strategy based upon the use of human donor eyes, proteomics, and gene array analyses. Alcon Ocular Genomics and Proteomics Symposium. 


  1. Anthony SM, Van Braeckel-Budimir N, Moioffer SJ, et al. Protective function and durability of mouse lymph node-resident memory CD8+ T cells. Elife. 2021;10:e68662. Published 2021 Jun 18. doi:10.7554/eLife.68662
  2. Zouache MA, Silvestri G, Amoaku WM, et al. Comparison of the Morphology of the Foveal Pit Between African and Caucasian Populations. Transl Vis Sci Technol. 2020;9(5):24. Published 2020 Apr 28. doi:10.1167/tvst.9.5.24
  3. Van Braeckel-Budimir N, Varga SM, Badovinac VP, Harty JT. Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8+ T Cells and Heterosubtypic Immunity. Cell Rep. 2018;24(13):3374-3382.e3. doi:10.1016/j.celrep.2018.08.073
  4. Van Braeckel-Budimir N, Gras S, Ladell K, et al. A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene. Immunity. 2017;47(5):835-847.e4. doi:10.1016/j.immuni.2017.10.013
  5. Kim MT, Harty JT. Splenectomy Alters Distribution and Turnover but not Numbers or Protective Capacity of de novo Generated Memory CD8 T-Cells. Front Immunol. 2014;5:568. Published 2014 Nov 6. doi:10.3389/fimmu.2014.00568
  6. Slutter B, Pewe LL, Kaech SM, Harty JT. Lung airway-surveilling CSCR3(hi) memory CD8 (+) T cells are critical for protection against influenza A virus. Immunity. 2013 Nov 14;39(5):939-48.
  7. Richer MJ, Nolz JC, Harty JT. Pathogen-specific inflammatory milieu tune the antigen sensitivity of CD8(+) T cells by enhancing T cell receptor signaling. Immunity. 2013 Jan 24;38(1):140-52.  Epub 2012 Dec 20.
  8. Schmidt NW, Butler NS, and Harty JT. Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity. Journal of Immunology. 2011 May;186(10):5873-5884.
  9. Butler NS, Schmidt NW, Vaughan AM, Aly AS, Kappe SH, Harty JT. Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites. Cell Host Microbe. 2011;9(6):451-462. doi:10.1016/j.chom.2011.05.008
  10. Nolz JC, Harty JT. Protective capacity of memory CD8+ T cells is dictated by antigen exposure history and nature of the infection. Immunity. 2011;34(5):781-793. doi:10.1016/j.immuni.2011.03.020
  11. Karen M. Gehrs, MD; Jared R. Jackson, BS; Eric N. Brown, PhD; Rando Allikmets, PhD; Gregory S. Hageman, PhD. 2010. Complement, Age-Related Macular Degeneration and a Vision of the Future. Arch Ophthalmol. 128(3):349-358.
  12. Una Kelly, Ling Yu, Pallavi Kumar, Jin-Dong Ding, Haixiang Jiang, Gregory S. Hageman, Vadim Y. Arshavsky, Michael M. Frank, Michael A. Hauser and Catherine Bowes Rickman. 2010. Heparan Sulfate, Including that in Bruch's Membrane, Inhibits the Complement Alternative Pathway: Implications for Age-Related Macular Degeneration. J. of Immunol. doi:10.4049/jimmunol.0903596.
  13. Una Kelly, Catherine Bowes Rickman, Eric A. Postel, Michael A. Hauser, Gregory S. Hageman, Vadim Y. Arshavsky, and Nikolai P. Skiba. 2009. Rapid and Sensitive Method for Detection of Y402, H402, I62, and V62 Variants of Complement Factor H in Human Plasma Samples Using Mass Spectrometry. Invest. Ophthalmol. Vis. Sci. 50:1540-1545.
  14. Robert F. Mullins, Stephen R. Russell, Don H. Anderson and Gregory S. Hageman. 2000. Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. The FASEB Journal. 14:835-846.
  15. Gregory S. Hageman, Phil J. Luthert, N. H. Victor Chong, Lincoln V. Johnson, Don H. Anderson and Robert F. Mullins. 2001. An Integrated Hypothesis That Considers Drusen as Biomarkers of Immune-Mediated Processes at the RPE-Bruch's Membrane Interface in Aging and Age-Related Macular Degeneration. Progress in Retinal and Eye Research. 20(6):705-732.
  16. Q. Wang, C. D. Sigmund, J. J.-C. Lin. 2000. Identification of cis Elements in the Cardiac Troponin T Gene Conferring Specific Expression in Cardiac Muscle of Transgenic Mice. Circulation Research. 86:478-484.
  17. Robin L. Davisson, Yueming Ding, David E. Stec, James F. Catterall and Curt D. Sigmund. 1999. Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. Physiological Genomics 1:3-9.
  18. Patrick L. Sinn, Xiaoji Zhang and Curt D. Sigmund. 1999. JG cell expression and partial regulation of a human renin genomic transgene driven by a minimal renin promoter. Am J Physiol Renal Physiol 277:F634-F642.
  19. Gongyu Yang and Curt D. Sigmund. 1998. Developmental expression of human angiotensinogen in transgenic mice. Am J Physiol Renal Physiol. 274(5):F932-F939.
  20. Gongyu Yang and Curt D. Sigmund. 1998. Regulatory Elements Required for Human Angiotensinogen Expression in HepG2 Cells Are Dispensable in Transgenic Mice. Hypertension. 31:734-740.
  21. Kristy D. Lake-Bruse, Frank M. Faraci, Edward G. Shesely, Nobuyo Maeda, Curt D. Sigmund, and Donald D. Heistad (With the Technical Assistance of Kara L. Brown). 1998. Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice. Am J Physiol Heart Circ Physiol 277:H770-H776.
  22. Robin L. Davisson, Gongyu Yang, Terry G. Beltz, Martin D. Cassell, Alan Kim Johnson and Curt D. Sigmund. 1998. The Brain Renin-Angiotensin System Contributes to the Hypertension in Mice Containing Both the Human Renin and Human Angiotensinogen Transgenes. Circulation Research. 83;1047-1058.
  23. Yueming Ding, Robin L. Davisson, Dianne O. Hardy, Li-Ji Zhui, David C. Merrill, James F. Catteralli, and Curt D. Sigmund. 1997. The Kidney Androgen-regulated Protein Promoter Confers Renal Proximal Tubule Cell-specific and Highly Androgen-responsive Expression on the Human Angiotensinogen Gene in Transgenic Mice. J. of Biol. Chem. 272(44):28142-28148.